منابع مشابه
Experimental Autoimmune Encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). MS is also named encephalomyelitis disseminata (ED). EAE has been also called experimental allergic encephalomyelitis, but the word `allergic` is more and more replaced by the word `autoimmune`. This has to do with the deeper understanding of the disease biology that has been gathered over the last ye...
متن کاملExperimental autoimmune encephalomyelitis Experimental aspects of EAE
myelinating disease of the central nervous system (CNS) that takes a relapsing–remitting or a progressive course (reviewed in Refs 1,2). Its counterpart in the peripheral nervous system (PNS) is chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) (reviewed in Ref. 3). In addition, there are acute, monophasic disorders, such as the inflammatory demyelinating polyradiculoneuropathy t...
متن کاملA Domain Model of Experimental Autoimmune Encephalomyelitis
Experimentation with simulations of complex systems can be used to gain insights into those systems’ nature and operation. Such in silico experimentation represents a valuable tool that can complement conventional in vivo experimentation. Validation of a simulation’s representation of the real world system remains an open question in complex systems research. As the engineer of a complex system...
متن کاملContribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis
Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that Panx1-mediated ATP release contributes to expression of Experimental Autoimmune Encephalomyelitis (EAE), an animal model for multiple sclerosi...
متن کاملSilencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis.
IFN-γ-producing Th1 and IL-17-producing Th17 cells are the key participants in various autoimmune diseases, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Although both of these T cell subsets are known to be regulated by specific transcription factors and cytokines, the role of microRNAs that control these two inflammatory T cell subsets and...
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ژورنال
عنوان ژورنال: Biomedical Journal
سال: 2015
ISSN: 2319-4170
DOI: 10.4103/2319-4170.158500